The Acute Effects Of ATP-Sensitive Potassium Channel Opener (Pinacidil) And Blocker (Glimepride) On the Ischemia or Reperfusion-Induced Arrhythmias

Introduction: Myocardial ischemia due to coronary obstruction and reperfusion the opening of vessel occurring in acute stage myocardial infarction leads lethal arrhythmia sudden death humans. That is why pharmacological drug research decrease these arrhythmias have been researched intensively. In this study, effect administration pinacidil glimepride, on or reperfusion-induced was aimed be researched. Methods: Two groups were produced; first group, only produced by ligation left artery 20 minutes, second group 6 minutes subsequent 15 occluded artery. Drugs administered intravenously at 2 just following group. The ECG blood pressure recorded during reperfusion. type, duration, incidence arrhythmia, heart rate, pressure, rate from recording determined. All data compared one-way ANOVA. Then, with their control, control each other a one-tailed student t-test. between Ki square test. Results: Pinacidil significantly decreased score both period but glimepiride not effective when they given Discussion Conclusion: This study suggests that might candidate for drugs can used more needed reveal antiarrhythmic proarrhythmic glimepride infarction.